Phillips Patrick C
Center for Ecology and Evolution, University of Oregon, Eugene, Oregon 97403 USA.
Nat Rev Genet. 2008 Nov;9(11):855-67. doi: 10.1038/nrg2452.
Epistasis, or interactions between genes, has long been recognized as fundamentally important to understanding the structure and function of genetic pathways and the evolutionary dynamics of complex genetic systems. With the advent of high-throughput functional genomics and the emergence of systems approaches to biology, as well as a new-found ability to pursue the genetic basis of evolution down to specific molecular changes, there is a renewed appreciation both for the importance of studying gene interactions and for addressing these questions in a unified, quantitative manner.
上位性,即基因之间的相互作用,长期以来一直被认为对于理解遗传途径的结构和功能以及复杂遗传系统的进化动态至关重要。随着高通量功能基因组学的出现、生物学系统方法的兴起,以及深入探究进化的遗传基础直至特定分子变化的新能力,人们重新认识到研究基因相互作用的重要性,并以统一、定量的方式解决这些问题。