Tabernaemontana divaricata 中的细胞毒吲哚生物碱。
Cytotoxic indole alkaloids from Tabernaemontana divaricata.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
出版信息
J Nat Prod. 2013 Aug 23;76(8):1406-12. doi: 10.1021/np400130y. Epub 2013 Aug 15.
Five new vobasinyl-ibogan-type bisindole alkaloids, tabernaricatines A-E (1-5), two new monomers, tabernaricatines F and G (6 and 7), and 24 known indole alkaloids were isolated from the aerial parts of Tabernaemontana divaricata. Alkaloids 1 and 2 are the first vobasinyl-ibogan-type alkaloids possessing a six-membered ring via an ether linkage between C-17 and C-21. All compounds except for 3 were evaluated for their cytotoxicity against five human cancer cell lines; conophylline showed significant bioactivity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cells with IC₅₀ values of 0.17, 0.35, 0.21, 1.02, and 1.49 μM, respectively.
从 Tabernaemontana divaricata 的地上部分分离得到了五个新的 vobasinyl-ibogan 型双吲哚生物碱，即 tabernaricatines A-E（1-5），两个新的单体，tabernaricatines F 和 G（6 和 7），以及 24 个已知的吲哚生物碱。化合物 1 和 2 是第一个通过 C-17 和 C-21 之间的醚键连接形成六元环的 vobasinyl-ibogan 型生物碱。除了 3 之外，所有化合物都被评估了对五种人癌细胞系的细胞毒性；conophylline 对 HL-60、SMMC-7721、A-549、MCF-7 和 SW480 细胞表现出显著的生物活性，IC₅₀ 值分别为 0.17、0.35、0.21、1.02 和 1.49 μM。
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