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Web 3DNA——一个用于三维核酸结构分析、重建和可视化的网络服务器。

Web 3DNA--a web server for the analysis, reconstruction, and visualization of three-dimensional nucleic-acid structures.

作者信息

Zheng Guohui, Lu Xiang-Jun, Olson Wilma K

机构信息

Department of Chemistry & Chemical Biology, BioMaPS Institute for Quantitative Biology, Wright-Rieman Laboratories, Rutgers, State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA.

出版信息

Nucleic Acids Res. 2009 Jul;37(Web Server issue):W240-6. doi: 10.1093/nar/gkp358. Epub 2009 May 27.

Abstract

The w3DNA (web 3DNA) server is a user-friendly web-based interface to the 3DNA suite of programs for the analysis, reconstruction, and visualization of three-dimensional (3D) nucleic-acid-containing structures, including their complexes with proteins and other ligands. The server allows the user to determine a wide variety of conformational parameters in a given structure--such as the identities and rigid-body parameters of interacting nucleic-acid bases and base-pair steps, the nucleotides comprising helical fragments, etc. It is also possible to build 3D models of arbitrary nucleotide sequences and helical types, customized single-stranded and double-helical structures with user-defined base-pair parameters and sequences, and models of DNA 'decorated' at user-defined sites with proteins and other molecules. The visualization component offers unique, publication-quality representations of nucleic-acid structures, such as 'block' images of bases and base pairs and stacking diagrams of interacting nucleotides. The w3DNA web server, located at http://w3dna.rutgers.edu, is free and open to all users with no login requirement.

摘要

w3DNA(网络3DNA)服务器是一个用户友好的基于网络的界面,用于访问3DNA程序套件,该套件用于分析、重建和可视化三维(3D)含核酸结构,包括它们与蛋白质和其他配体的复合物。该服务器允许用户确定给定结构中的各种构象参数,例如相互作用的核酸碱基和碱基对步的身份和刚体参数、构成螺旋片段的核苷酸等。还可以构建任意核苷酸序列和螺旋类型的3D模型、具有用户定义碱基对参数和序列的定制单链和双链结构,以及在用户定义位点用蛋白质和其他分子“装饰”的DNA模型。可视化组件提供核酸结构的独特、可用于发表的表示形式,例如碱基和碱基对的“块状”图像以及相互作用核苷酸的堆积图。w3DNA网络服务器位于http://w3dna.rutgers.edu,免费向所有用户开放,无需登录。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb24/2703980/3da2fca46dc0/gkp358f1.jpg

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