采用宽带超发光二极管光源的超高分辨率光学相干断层扫描成像

Ultrahigh resolution optical coherence tomography imaging with a broadband superluminescent diode light source.

作者信息

Ko Tony, Adler Desmond, Fujimoto James, Mamedov Dmitry, Prokhorov Viatcheslav, Shidlovski Vladimir, Yakubovich Sergei

出版信息

Opt Express. 2004 May 17;12(10):2112-9. doi: 10.1364/opex.12.002112.

DOI:10.1364/opex.12.002112

PMID:19475046

Abstract

Ultrahigh resolution optical coherence tomography imaging is performed with a compact broadband superluminescent diode light source. The source consists of two multiplexed broadband superluminescent diodes and has a power output of 4 mW with a spectral bandwidth of 155 nm, centered at a wavelength of 890 nm. In vivo imaging was performed with approximately 2.3 microm axial resolution in scattering tissue and approximately 3.2 microm axial resolution in the retina. These results demonstrate that it is possible to perform in vivo ultrahigh resolution optical coherence tomography imaging using a superluminescent diode light source that is inexpensive, compact, and easy to operate.

摘要

超高分辨率光学相干断层扫描成像采用紧凑型宽带超发光二极管光源进行。该光源由两个复用的宽带超发光二极管组成，功率输出为4毫瓦，光谱带宽为155纳米，中心波长为890纳米。在体内成像中，在散射组织中的轴向分辨率约为2.3微米，在视网膜中的轴向分辨率约为3.2微米。这些结果表明，使用廉价、紧凑且易于操作的超发光二极管光源进行体内超高分辨率光学相干断层扫描成像是可行的。