Department of Endocrinology, MEDWIN Hospitals, Hyderabad, AP, India.
Indian J Pediatr. 2009 Sep;76(9):933-5. doi: 10.1007/s12098-009-0153-7. Epub 2009 May 27.
To study the relation between body mass index (BMI) and TSH in euthyroid and subclinical hypothyroid obese children and compared serum TSH level among obese and overweight children.
Fifty consecutive children (aged 2-18 yr) presenting for obesity were studied. All cases with TSH > 10, low T3/T4, organic and syndromic obesity were excluded. Patients were divided into Group 1: Overweight (n=20) (BMI between 85(th) to 95(th) centile) and Group 2: Obesity (n=30) (BMI > 95(th) centile). Fisher's exact test, Mann-Whitney U test and Pearson's correlation were used for statistical analysis. P value < 0.05 was considered significant.
Elevated TSH level (between 4.5-10 mIU/L) with normal T3, T4 was seen in 4/20 overweight and 9/30 of obese children (P=0.5219). The mean TSH was comparable in both the groups (3.22 +/- 3.1 mIU/L vs. 3.63 +/- 2.2 mIU/L, P=0.3491). Overall TSH showed no correlation with BMI (r= 0.0014, P=0.9924).
The preliminary data did not show any relation between severity of obesity and TSH level. Further large scale data from population are required to confirm these findings.
研究正常甲状腺功能且亚临床甲状腺功能减退肥胖儿童的体重指数（BMI）与 TSH 之间的关系，并比较肥胖和超重儿童的血清 TSH 水平。
连续研究了 50 名（年龄 2-18 岁）因肥胖就诊的儿童。排除了 TSH>10、T3/T4 降低、有机和综合征性肥胖的病例。患者分为 1 组：超重（n=20）（BMI 在第 85-95 百分位之间）和 2 组：肥胖（n=30）（BMI>第 95 百分位）。Fisher 确切检验、Mann-Whitney U 检验和 Pearson 相关分析用于统计分析。P 值<0.05 被认为具有统计学意义。
超重儿童中（n=4）和肥胖儿童中（n=9），4/20 和 9/30 的 TSH 水平升高（4.5-10 mIU/L），但 T3、T4 正常（P=0.5219）。两组的平均 TSH 水平相当（3.22±3.1 mIU/L 比 3.63±2.2 mIU/L，P=0.3491）。总体而言，TSH 与 BMI 无相关性（r=0.0014，P=0.9924）。
初步数据未显示肥胖严重程度与 TSH 水平之间存在任何关系。需要来自人群的更大规模数据来证实这些发现。
