Department of Microbiology, M.L.N. Medical College, Allahabad, India.
Indian J Pediatr. 2009 Sep;76(9):917-9. doi: 10.1007/s12098-009-0142-x. Epub 2009 May 27.
To assess the prevalence of viral co-infections in HIV infected children.
Children born to HIV seropositive parents and those children who were suspected to be HIV infected based on clinical presentation by the pediatrician were screened for HIV -1 and 2 antibodies as per National Aids Control Organization (NACO) guidelines. Those found to be seropositive for HIV infection were further tested for Hepatitis B&C, Herpes simplex virus and Human cytomegalovirus infection.
Among 803 children screened, 101 were found positive for HIV antibodies. Among the five viral markers tested, HCMV IgG was positive in 88 children (87.1%). HCMV IgM was positive in 35 cases (34.6%). HBsAg tested positive in 30 children, while anti-HCV IgM was reactive in 27 cases. IgM anti- HSV antibodies were observed positive in 59 (58.4%) cases. Both hepatitis virus coinfection (HBsAg and anti- HCV IgM antibodies) was observed in 10 HIV positive children, while both Herpesviridae family viruses (HCMV -IgM antibodies and HSV -IgM antibodies) were positive in 30 cases (29.7%).
Viral co-infections are significantly higher in HIV positive children, which adds to significant mortality and morbidity and should therefore be screened in all HIV positive children for timely treatment in order to improve the quality of life and better survival of HIV infected children.
评估 HIV 感染儿童中病毒合并感染的流行情况。
根据国家艾滋病控制组织（NACO）的指南，对 HIV 血清阳性父母所生的儿童以及儿科医生根据临床表现怀疑感染 HIV 的儿童进行 HIV-1 和 2 抗体筛查。对 HIV 感染血清阳性的儿童进一步检测乙型肝炎和丙型肝炎、单纯疱疹病毒和人巨细胞病毒感染。
在筛查的 803 名儿童中，有 101 名 HIV 抗体阳性。在检测的五种病毒标志物中，88 名儿童（87.1%）的 HCMV IgG 阳性。35 例（34.6%）HCMV IgM 阳性。30 名儿童 HBsAg 阳性，27 例抗 HCV IgM 阳性。59 例（58.4%）观察到 IgM 抗单纯疱疹病毒抗体阳性。10 名 HIV 阳性儿童同时存在两种肝炎病毒合并感染（HBsAg 和抗 HCV IgM 抗体），30 名儿童同时存在两种疱疹病毒科病毒（HCMV-IgM 抗体和 HSV-IgM 抗体）阳性。
HIV 阳性儿童的病毒合并感染率明显较高，这会增加其死亡率和发病率，因此应在所有 HIV 阳性儿童中进行筛查，以便及时进行治疗，从而提高 HIV 感染儿童的生活质量和更好的生存机会。
