Mizukami Katsuyoshi, Homma Toshiaki, Aonuma Kazutaka, Kinoshita Toru, Kosaka Kenji, Asada Takashi
Department of Psychiatry, University of Tsukuba, Tsukuba City, Ibaraki, Japan.
Ann Neurol. 2009 May;65(5):614-7. doi: 10.1002/ana.21613.
A systematic autonomic dysfunction observed among patients with dementia with Lewy bodies (DLB) has recently attracted close attention. Here, we compare cardiovascular and pulmonary autonomic functions among patients with DLB, patients with Alzheimer's disease, and healthy control subjects. All 15 DLB patients demonstrated severely low ventilatory response to hypercapnia, whereas none of the other subjects demonstrated abnormal results. The majority of the DLB patients showed impaired heart rate variability, low uptake on (123)I-metaiodobenzylguanidine myocardial scintigraphy, and orthostatic hypotension. Ventilatory response to hypercapnia as a marker of respiratory autonomic function is a promising diagnostic tool for DLB.
最近，路易体痴呆（DLB）患者中观察到的系统性自主神经功能障碍引起了密切关注。在此，我们比较了DLB患者、阿尔茨海默病患者和健康对照者的心血管和肺部自主神经功能。所有15例DLB患者对高碳酸血症的通气反应均严重低下，而其他受试者均未出现异常结果。大多数DLB患者表现出心率变异性受损、（123）I-间碘苄胍心肌闪烁显像摄取低下和体位性低血压。作为呼吸自主神经功能标志物的对高碳酸血症的通气反应是DLB一种很有前景的诊断工具。
