Wei Shaopeng, Wang Mingan, Zhang Jiwen, Qian Yong, Ji Zhiqin, Wu Wenjun
Institute of Pesticide Science, Northwest Agricultural & Forestry University, Shaanxi 712100, China.
Nat Prod Commun. 2009 Apr;4(4):461-6.
Three new sesquiterpene polyol esters with a beta-dihydroagarofuran skeleton, NW12 (1), NW27 (2), and NW31 (4), together with a known compound, NW30 (3), were isolated from the root bark of Celastrus angulatus. Their chemical structures were elucidated by analyses of MS and NMR spectral data. Preliminary insecticidal and antitumor activities of these compounds were evaluated. Compounds 1-4 showed moderate stomach toxicity against Mythimna separata, and their KD50 values were 673.6, 1121.3, 1720.0 and 548.6 microg/g, respectively. Only 1 and 3 exhibited slight antitumor activity against human breast cancer cell line (Bcap-37), and their IC50 values were all above 50 microM.
从苦皮藤根皮中分离得到了三种具有β-二氢沉香呋喃骨架的新型倍半萜多元醇酯NW12（1）、NW27（2）和NW31（4），以及一种已知化合物NW30（3）。通过对质谱和核磁共振光谱数据的分析阐明了它们的化学结构。对这些化合物的杀虫和抗肿瘤活性进行了初步评价。化合物1-4对粘虫表现出中等胃毒活性，其半数致死剂量（KD50）值分别为673.6、1121.3、1720.0和548.6微克/克。只有1和3对人乳腺癌细胞系（Bcap-37）表现出轻微的抗肿瘤活性，其半数抑制浓度（IC50）值均高于50微摩尔。
