Shojaie Mohammad, Sotoodah Abdoreza, Shafaie Ghafar
Cardiology Department, Jahrom Medical University, Jahrom, Iran.
Lipids Health Dis. 2009 May 28;8:17. doi: 10.1186/1476-511X-8-17.
Adiponectin is an adipose tissue-derived mediator with significant anti-atherogenic properties. A few studies were done in acute phase of myocardial infarction especially in non obese patients. We design a study to investigate the association between adiponectin concentration and acute phase of myocardial infarction in non obese patients.
This case-control study was done in Paymaneah Hospital (Jahrom, Iran) from Feb 2007 to May 2008. Plasma adiponectin levels were measured in 43 patients with AMI (mean age: 62.7 +/- 13.3 years, male: 67.4%) at the first 24 hours of admission and 43 normal controls (mean age: 62.1 +/- 12.3 years, male: 55.8%) matched for age, sex and other CAD risk factors.
Adiponectin levels in patients with AMI (3.36 microg/mL) were significantly lower than that of the control group (5.03 microg/mL) (p < 0.0001). Lower adiponectin were independently associated with higher risk of AMI (odds ratio = 8.97; 95% CIs: 2.3-34.5; p = 0.001). Adiponectin levels negatively correlated with triglyceride (r = -0.46, p = 0.002) and total cholesterol (r = -0.32, p = 0.03) in the case group and with body mass index (BMI) in control subjects.
The present study showed that adiponectin was associated with AMI in non obese patients but it is not related to sex, age and other CAD risk factors.
脂联素是一种源自脂肪组织的介质，具有显著的抗动脉粥样硬化特性。此前针对心肌梗死急性期开展了一些研究，特别是在非肥胖患者中。我们设计了一项研究，以调查非肥胖患者脂联素浓度与心肌梗死急性期之间的关联。
本病例对照研究于2007年2月至2008年5月在伊朗贾赫罗姆的佩亚梅纳医院进行。在入院的头24小时内，对43例急性心肌梗死患者（平均年龄：62.7±13.3岁，男性占67.4%）和43名年龄、性别及其他冠心病危险因素相匹配的正常对照者（平均年龄：62.1±12.3岁，男性占55.8%）测定血浆脂联素水平。
急性心肌梗死患者的脂联素水平（3.36微克/毫升）显著低于对照组（5.03微克/毫升）（p<0.0001）。较低的脂联素水平与急性心肌梗死的较高风险独立相关（优势比=8.97；95%可信区间：2.3 - 34.5；p = 0.001）。病例组中脂联素水平与甘油三酯（r = -0.46，p = 0.002）和总胆固醇（r = -0.32，p = 0.03）呈负相关，而在对照组中与体重指数（BMI）呈负相关。
本研究表明，脂联素与非肥胖患者的急性心肌梗死有关，但与性别、年龄及其他冠心病危险因素无关。
