Mahgoub Kamal Ahmed Marghany, Abd El Moutaleb Ashraf Taha
Department of Cardiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
J Egypt Soc Parasitol. 2010 Aug;40(2):489-98.
Adiponectin is an adipose tissue derived mediator with significant anti atherosclerotic properties and is involved in the regulation of insulin sensitivity and lipid oxidation, a few studies were done in acute phase of myocardial infarction, especially in none obese patients. The study investigated the association between adiponectin concentration and acute phase of myocardial infarction (MI) in non obese men patients. The results showed that adiponectin levels in patients with AMI (5.2ug/ml) were significantly lower than that of control group (7.5ug/ml) (P<0.001). Lower adiponectin levels were independently associated with higher risk of AMI (odd ratio= 6.12, 95%CIs: 2.4- 18.6; P=<0.001).Adiponectin levels were negatively correlated with triglyceride (r=-0.34) in case group and (r=- 0.41) in control group (P< 0.001). In addition, negatively correlated with BMI(r=-0.27) in case group and (r=-0.23) in control group (P< 0.001), but adiponectin levels is positively correlated with HDL-Cholesterol (r= 0.45) in case group and (r=0.51) in control group with (P<0.001).
脂联素是一种源自脂肪组织的介质，具有显著的抗动脉粥样硬化特性，并参与胰岛素敏感性和脂质氧化的调节，一些研究是在心肌梗死急性期进行的，尤其是在非肥胖患者中。该研究调查了非肥胖男性患者脂联素浓度与心肌梗死（MI）急性期之间的关联。结果显示，急性心肌梗死患者的脂联素水平（5.2微克/毫升）显著低于对照组（7.5微克/毫升）（P<0.001）。较低的脂联素水平与急性心肌梗死的较高风险独立相关（优势比=6.12，95%置信区间：2.4-18.6；P=<0.001）。病例组中脂联素水平与甘油三酯呈负相关（r=-0.34），对照组中（r=-0.41）（P<0.001）。此外，病例组中与体重指数呈负相关（r=-0.27），对照组中（r=-0.23）（P<0.001），但病例组中脂联素水平与高密度脂蛋白胆固醇呈正相关（r=0.45），对照组中（r=0.51）（P<0.001）。
