Gugliotta Giuseppe, Botta Mauro, Giovenzana Giovanni Battista, Tei Lorenzo
Dipartimento di Scienze dell'Ambiente e della Vita, Università degli Studi del Piemonte Orientale A. Avogadro, Viale T. Michel 11, 15121 Alessandria, Italy.
Bioorg Med Chem Lett. 2009 Jul 1;19(13):3442-4. doi: 10.1016/j.bmcl.2009.05.024. Epub 2009 May 10.
Novel bifunctional agents based on the AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) structure with hydroxyl, carboxyl and chloro functional groups were prepared. The Gd(III) complexes show optimal magnetic properties making them very good candidates for conjugation to biomolecules for molecular imaging applications. An example of conjugation to a bile acid derivative is also reported.
制备了基于AAZTA（6-氨基-6-甲基全氢-1,4-二氮杂环庚烷四乙酸）结构且带有羟基、羧基和氯官能团的新型双功能试剂。钆（III）配合物显示出最佳磁性能，使其成为用于分子成像应用中与生物分子偶联的非常好的候选物。还报道了与胆汁酸衍生物偶联的一个例子。
