糖原合成酶激酶3在阿尔茨海默病中的作用。
The role of GSK3 in Alzheimer disease.
作者信息
Hernández Félix, de Barreda Elena Gómez, Fuster-Matanzo Almudena, Goñi-Oliver Paloma, Lucas José J, Avila Jesús
机构信息
Centro de Bioligía Molecular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid, Campus Cantoblanco, 28049 Madrid, Spain.
出版信息
Brain Res Bull. 2009 Oct 28;80(4-5):248-50. doi: 10.1016/j.brainresbull.2009.05.017. Epub 2009 May 27.
Mutations in app, ps-1 and ps-2 genes result in the appearance of Familial Alzheimer disease (FAD). Although, in many cases, those mutations result in an increase of the amount of beta amyloid peptide, there is not a clear correlation between that amount and the time of the onset of the disease. Thus, other factors may explain how mutations in those genes result in the appearance of neurodegeneration. In this minireview we propose that GSK3 could be one of those factors.
APP、PS-1和PS-2基因的突变会导致家族性阿尔茨海默病（FAD）的出现。尽管在许多情况下，这些突变会导致β淀粉样肽数量增加，但该数量与疾病发病时间之间并没有明确的相关性。因此，其他因素可能解释这些基因的突变如何导致神经退行性变的出现。在这篇小型综述中，我们提出糖原合酶激酶3（GSK3）可能是这些因素之一。
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