Uhlhaas Peter J, Roux Frederic, Singer Wolf, Haenschel Corinna, Sireteanu Ruxandra, Rodriguez Eugenio
Department of Neurophysiology, Max Planck Institute for Brain Research, 60528 Frankfurt am Main, Germany.
Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9866-71. doi: 10.1073/pnas.0900390106. Epub 2009 May 28.
Brain development is characterized by maturational processes that span the period from childhood through adolescence to adulthood, but little is known whether and how developmental processes differ during these phases. We analyzed the development of functional networks by measuring neural synchrony in EEG recordings during a Gestalt perception task in 68 participants ranging in age from 6 to 21 years. Until early adolescence, developmental improvements in cognitive performance were accompanied by increases in neural synchrony. This developmental phase was followed by an unexpected decrease in neural synchrony that occurred during late adolescence and was associated with reduced performance. After this period of destabilization, we observed a reorganization of synchronization patterns that was accompanied by pronounced increases in gamma-band power and in theta and beta phase synchrony. These findings provide evidence for the relationship between neural synchrony and late brain development that has important implications for the understanding of adolescence as a critical period of brain maturation.
大脑发育的特点是成熟过程贯穿从童年到青少年再到成年的时期，但对于这些阶段的发育过程是否以及如何不同，人们知之甚少。我们通过测量68名年龄在6至21岁之间的参与者在格式塔感知任务期间脑电图记录中的神经同步性，分析了功能网络的发育情况。在青春期早期之前，认知表现的发育改善伴随着神经同步性的增加。这个发育阶段之后，在青春期后期出现了神经同步性意外下降，这与表现下降有关。在这段不稳定期之后，我们观察到同步模式的重新组织，同时伽马波段功率以及theta和beta相位同步性显著增加。这些发现为神经同步性与大脑后期发育之间的关系提供了证据，这对于理解青春期作为大脑成熟的关键时期具有重要意义。
