Gonzalo Nieves, Serruys Patrick W, García-García Héctor M, van Soest Gijs, Okamura Takayuki, Ligthart Jurgen, Knaapen Michiel, Verheye Stefan, Bruining Nico, Regar Evelyn
Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, Países Bajos.
Rev Esp Cardiol. 2009 Jun;62(6):615-24. doi: 10.1016/s1885-5857(09)72225-x.
The relationship between the lumen dimensions obtained in human coronary arteries using intravascular ultrasound (IVUS) and those obtained using optical coherence tomography (OCT) is not well understood. The objectives were to compare the lumen measurements obtained ex vivo in human coronary arteries using IVUS, OCT and histomorphometry, and in vivo in patients using IVUS and OCT with and without balloon occlusion.
Ex vivo study: the lumen areas of matched anatomical sections of human coronary arteries were measured using IVUS, OCT and histology. In vivo study: the lumen areas in matched sections were measured using IVUS and OCT with and without occlusion.
Ex vivo: in the eight specimens studied, the lumen area obtained using OCT and IVUS was larger than that obtained using histomorphometry: mean difference 0.8+/-1 mm(2) (28%) for OCT and 1.3+/-1.1 mm(2) (40%) for IVUS. In vivo: in the five vessels analyzed, the lumen area obtained using IVUS was larger than that obtained using OCT: mean difference 1.67+/-0.54 mm(2) (33.7%) for IVUS relative to OCT with occlusion and 1.11+/-0.53 mm(2) (21.5%) relative to OCT without occlusion. The lumen area obtained using OCT without occlusion was larger than that obtained using OCT with occlusion: mean difference 0.61+/-0.23 mm(2) (13%).
In fixed human coronary arteries, both IVUS and OCT overestimated the lumen area compared with histomorphometry. In vivo the lumen dimensions obtained using IVUS were larger than those obtained using OCT, with or without occlusion. Moreover, the OCT image acquisition technique (i.e. with or without occlusion) also had an impact on lumen measurement.
血管内超声（IVUS）和光学相干断层扫描（OCT）所测得的人体冠状动脉管腔尺寸之间的关系尚未完全明确。目的是比较使用IVUS、OCT和组织形态测量法在人体冠状动脉离体状态下获得的管腔测量值，以及在患者体内使用IVUS和OCT并进行或不进行球囊闭塞时获得的管腔测量值。
离体研究：使用IVUS、OCT和组织学方法测量人体冠状动脉匹配解剖切片的管腔面积。体内研究：使用IVUS和OCT在有或无闭塞情况下测量匹配切片的管腔面积。
离体研究：在研究的8个标本中，使用OCT和IVUS获得的管腔面积大于使用组织形态测量法获得的管腔面积：OCT的平均差异为0.8±1mm²（28%），IVUS的平均差异为1.3±1.1mm²（40%）。体内研究：在分析的5条血管中，使用IVUS获得的管腔面积大于使用OCT获得的管腔面积：相对于有闭塞的OCT，IVUS的平均差异为1.67±0.54mm²（33.7%），相对于无闭塞的OCT，平均差异为1.11±0.53mm²（21.5%）。使用无闭塞的OCT获得的管腔面积大于使用有闭塞的OCT获得的管腔面积：平均差异为0.61±0.23mm²（13%）。
在固定的人体冠状动脉中，与组织形态测量法相比，IVUS和OCT均高估了管腔面积。在体内，无论有无闭塞，使用IVUS获得的管腔尺寸均大于使用OCT获得的管腔尺寸。此外，OCT图像采集技术（即有或无闭塞）也对管腔测量有影响。
