El Karim Ikhlas A, Linden Gerard J, Irwin Chris R, Lundy Fionnuala T
Department of Restorative Dentistry, School of Dentistry, Royal Group of Hospitals, Belfast, United Kingdom.
J Endod. 2009 Jun;35(6):829-33. doi: 10.1016/j.joen.2009.03.005. Epub 2009 Apr 19.
Neuropeptides play an important role in inflammation and repair and have been implicated in mediating angiogenesis. Pulp fibroblasts express neuropeptide receptors, and the aim of this research was to investigate whether neuropeptides could regulate angiogenic growth factor expression in vitro
An angiogenic array was used to determine the levels of 10 angiogenic growth factors expressed by human pulp fibroblasts.
Pulp fibroblasts were shown to express angiogenin, angiopoietin-2, epidermal growth factor, basic fibroblast growth factor, heparin-binding epidermal growth factor, hepatocyte growth factor, leptin, platelet-derived growth factor, placental growth factor, and vascular endothelial growth factor. Furthermore, the neuropeptides substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide, and neuropeptide Y altered angiogenic growth factor expression in vitro.
The regulation of angiogenic growth factor expression by neuropeptides suggests a novel role for neuropeptides in pulpal inflammation and repair.
神经肽在炎症和修复过程中发挥重要作用，并被认为参与介导血管生成。牙髓成纤维细胞表达神经肽受体，本研究的目的是调查神经肽是否能在体外调节血管生成生长因子的表达。
使用血管生成阵列来测定人牙髓成纤维细胞表达的10种血管生成生长因子的水平。
牙髓成纤维细胞被证明表达血管生成素、血管生成素-2、表皮生长因子、碱性成纤维细胞生长因子、肝素结合表皮生长因子、肝细胞生长因子、瘦素、血小板衍生生长因子、胎盘生长因子和血管内皮生长因子。此外，神经肽P物质、降钙素基因相关肽、血管活性肠肽和神经肽Y在体外改变了血管生成生长因子的表达。
神经肽对血管生成生长因子表达的调节表明神经肽在牙髓炎症和修复中具有新的作用。
