Shao B R, Huang Z S, Shi X H, Meng F
Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, WHO Collaborating Centre for Malaria, Shanghai, People's Republic of China.
Southeast Asian J Trop Med Public Health. 1991 Mar;22(1):65-7.
The surveillance of sensitivity of P. falciparum to pyronaridine/sulfadoxine/pyrimethamine has been carried out in Diaoluo area in Hainan Province where chloroquine-resistant falciparum malaria is endemic, covering an area of 406 square kilometers, with a population of 3745 in 1986. From 1986 all outpatients diagnosed as falciparum malaria were administered with PND/S/P as the only antimalarial. In vivo sensitivity of P. falciparum was measured in some patients who were treated in hospital. It was demonstrated that P. falciparum in the Diaoluo area has retained its sensitivity to a single oral dose of PND/S/P of 500/1,000/50 mg with 100% cure rate for at least 5 years.
在海南省吊罗地区开展了恶性疟原虫对咯萘啶/磺胺多辛/乙胺嘧啶敏感性的监测。该地区是耐氯喹恶性疟的流行区，面积406平方公里，1986年人口为3745人。自1986年起，所有诊断为恶性疟的门诊病人均使用咯萘啶/磺胺多辛/乙胺嘧啶作为唯一的抗疟药。对部分住院治疗的患者测定了恶性疟原虫的体内敏感性。结果表明，吊罗地区的恶性疟原虫对500/1000/50毫克的咯萘啶/磺胺多辛/乙胺嘧啶单剂量口服仍保持敏感性，治愈率达100%，至少持续了5年。
