Ferguson R, Hammer Daniel, Elsner Ann, Webb Robert, Burns Stephen, Weiter John
Opt Express. 2004 Oct 18;12(21):5198-208. doi: 10.1364/opex.12.005198.
Real time, high-speed image stabilization with a retinal tracking scanning laser ophthalmoscope (TSLO) enables new approaches to established diagnostics. Large frequency range (DC to 19 kHz), wide-field (40-deg) stabilized Doppler flowmetry imaging was demonstrated in initial human subject tests. The fundus imaging method is a quasi-confocal line-scanning laser ophthalmoscope (LSLO). The retinal tracking system uses a confocal reflectometer with a closed loop optical servo system to lock onto features in the ocular fundus and automatically re-lock after blinks. By performing a slow scan with the laser line imager, frequency-resolved retinal perfusion and vascular flow images were obtained free of eye motion artifacts. Normal adult subjects and patients were tested with and without mydriasis to characterize flow imaging performance.
使用视网膜跟踪扫描激光检眼镜（TSLO）进行实时、高速图像稳定，为既定诊断带来了新方法。在最初的人体试验中展示了大频率范围（直流至19千赫）、宽视野（40度）的稳定多普勒血流成像。眼底成像方法为准共焦线扫描激光检眼镜（LSLO）。视网膜跟踪系统使用带有闭环光学伺服系统的共焦反射仪，以锁定眼底特征并在眨眼后自动重新锁定。通过用激光线成像仪进行慢扫描，获得了无眼动伪影的频率分辨视网膜灌注和血管流动图像。对正常成年受试者和患者进行了散瞳和未散瞳测试，以表征血流成像性能。
