Chui Toco Y P, Vannasdale Dean A, Burns Stephen A
School of Optometry, Indiana University, 800 E Atwater Avenue, Bloomington, IN 47405, USA.
Biomed Opt Express. 2012 Oct 1;3(10):2537-49. doi: 10.1364/BOE.3.002537. Epub 2012 Sep 13.
Retinal vascular diseases are a leading cause of blindness and visual disability. The advent of adaptive optics retinal imaging has enabled us to image the retinal vascular at cellular resolutions, but imaging of the vasculature can be difficult due to the complex nature of the images, including features of many other retinal structures, such as the nerve fiber layer, glial and other cells. In this paper we show that varying the size and centration of the confocal aperture of an adaptive optics scanning laser ophthalmoscope (AOSLO) can increase sensitivity to multiply scattered light, especially light forward scattered from the vasculature and erythrocytes. The resulting technique was tested by imaging regions with different retinal tissue reflectivities as well as within the optic nerve head.
视网膜血管疾病是导致失明和视力残疾的主要原因。自适应光学视网膜成像技术的出现使我们能够以细胞分辨率对视网膜血管进行成像，但由于图像的复杂性，包括许多其他视网膜结构的特征，如神经纤维层、神经胶质细胞和其他细胞，血管成像可能会很困难。在本文中，我们表明，改变自适应光学扫描激光检眼镜（AOSLO）共焦孔径的大小和中心位置可以提高对多重散射光的敏感度，特别是从血管和红细胞向前散射的光。通过对具有不同视网膜组织反射率的区域以及视神经乳头内部进行成像，对所得技术进行了测试。
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