Mujat Mircea, Lu Yang, Maguluri Gopi, Zhao Youbo, Iftimia Nicusor, Ferguson R Daniel
Physical Sciences, Inc., 20 New England Business Center, Andover, MA 01810, USA.
Biomed Opt Express. 2018 Dec 12;10(1):167-180. doi: 10.1364/BOE.10.000167. eCollection 2019 Jan 1.
The platform described here combines the non-invasive measurement of the retina/choroid structure and ocular blood flow based on optical coherence tomography (OCT) and wide-field semi-quantitative global flow visualization using line-scanning Doppler flowmetry (LSDF). The combination of these two imaging modalities within the same platform enables comprehensive assessment of blood flow in the retina and choroid in animals and human subjects for diagnostic purposes. Ultra-widefield vasculature visualization is demonstrated here for the first time without injecting additional contrast agents and based only on the motion of particles within the vasculature.
本文所述平台结合了基于光学相干断层扫描（OCT）的视网膜/脉络膜结构无创测量和使用线扫描多普勒血流仪（LSDF）的广域半定量整体血流可视化。在同一平台内将这两种成像方式结合起来，能够对动物和人类受试者的视网膜和脉络膜血流进行综合评估，以用于诊断目的。本文首次展示了无需注射额外造影剂、仅基于脉管系统内颗粒运动的超广域脉管系统可视化。
