Hammer Daniel X, Ferguson R Daniel, Magill John C, White Michael A, Elsner Ann E, Webb Robert H
Physical Sciences Incorporated, 20 New England Business Center, Andover, Massachusetts 01810, USA.
Appl Opt. 2003 Aug 1;42(22):4621-32. doi: 10.1364/ao.42.004621.
The effectiveness of image stabilization with a retinal tracker in a multifunction, compact scanning laser ophthalmoscope (TSLO) was demonstrated in initial human subject tests. The retinal tracking system uses a co confocal reflectometer with a closed-loop optical servo system to lock onto features in the fundus. The system is multifarious and modular to allow configuration for many research a clinical applications. Adult volunteers were tested without mydriasis to optimize the tracking instrumentation and to characterize imaging performance. The retinal tracking system achieves a bandwidth of greater than 1 kHz, which permits tracking at rates that greatly exceed the maximum rate of motion of the human eye. The TSLO system stabilized images to an accuracy of 0.05 deg in all test subjects during ordinary saccades with a velocity up to approximately 500 deg/s. Feature lock was maintained for minutes despite subject eye blinking. Even when nearly 1000 frames were coadded, image blur was minimal. Successful frame coaddition allowed image acquisition with decreased noise in low-light applications. The retinal tracking system significantly enhances the imaging capabilities of the scanning laser ophthalmoscope.
在最初的人体试验中，已证明视网膜追踪器在多功能紧凑型扫描激光眼科显微镜（TSLO）中的图像稳定效果。视网膜追踪系统使用带闭环光学伺服系统的共焦反射仪锁定眼底特征。该系统多样且模块化，可针对多种研究和临床应用进行配置。对成年志愿者进行测试时未散瞳，以优化追踪仪器并表征成像性能。视网膜追踪系统实现了大于1kHz的带宽，这使得追踪速率大大超过人眼的最大运动速率。在普通扫视期间，TSLO系统在所有测试对象中将图像稳定到0.05度的精度，速度高达约500度/秒。尽管受试者眨眼，特征锁定仍能保持数分钟。即使将近1000帧图像叠加，图像模糊也最小。成功的帧叠加允许在低光应用中采集噪声降低的图像。视网膜追踪系统显著增强了扫描激光眼科显微镜的成像能力。
