Levy D, Deshayes L, Guillemain B, Parodi A L
Int J Cancer. 1977 Jun 15;19(6):822-7. doi: 10.1002/ijc.2910190613.
Complement fixation (CF) and hematological studies were performed on 517 cows living in normal conditions in different geographical areas of France. The animals belonged to three different categories: (1) multiple or single case herds, in which lymphosarcomas had been detected in the past five years. (2) Leukemia free herds of high risk regions. (3) Leukemia free and apparently unexposed herds. Positive animals were found with both methods in the first two categories but not in the third. Persistent lymphocytosis and CF antibodies were more frequent in leukemia than in exposed but leukemia free herds. Approximately 2 times more animals were found positive by serologic than by hematologic tests. The mean geometrical titer of CF antibodies was higher in lymphocytotic than in normal animals and highest in lymphosarcomatous cows. Persistent lymphocytosis was first detected in 3-years-old animals whereas 22% of younger cows were positive in the CF test.
对生活在法国不同地理区域正常条件下的517头奶牛进行了补体结合（CF）和血液学研究。这些动物分为三类：（1）多例或单例病例牛群，在过去五年中检测到淋巴肉瘤。（2）高风险地区无白血病牛群。（3）无白血病且显然未接触过的牛群。在前两类中两种方法均检测到阳性动物，但第三类中未检测到。持续性淋巴细胞增多症和CF抗体在白血病牛群中比在接触过但无白血病的牛群中更常见。血清学检测呈阳性的动物数量约为血液学检测的两倍。淋巴细胞增多的奶牛中CF抗体的平均几何滴度高于正常动物，在淋巴肉瘤奶牛中最高。持续性淋巴细胞增多症最早在3岁动物中检测到，而22%的年轻奶牛CF检测呈阳性。
