Scadding Guy, Durham Stephen
Allergy and Clinical Immunology, Imperial College, London, UK.
J Asthma. 2009 May;46(4):322-34. doi: 10.1080/02770900902785729.
Allergen-specific sublingual immunotherapy is now recognized to be an efficacious and well-tolerated treatment for allergic rhinitis. Emerging treatment strategies are also aimed at the primary treatment of allergic asthma, particularly allergy to house dust mites. Knowledge of the exact mechanisms of action of sublingual immunotherapy is at a basic level, although there appear to be similarities to the immunological changes seen in subcutaneous immunotherapy. An improved understanding should allow the development of more effective treatment programs and widen the potential use of this form of immunotherapy. This review discusses the possible mechanism of action of sublingual immunotherapy, including data from animal and clinical studies, while comparing this with the current understanding of subcutaneous immunotherapy.
变应原特异性舌下免疫疗法目前被认为是一种治疗变应性鼻炎的有效且耐受性良好的方法。新兴的治疗策略也旨在对变应性哮喘进行初步治疗，尤其是对屋尘螨过敏。尽管舌下免疫疗法的具体作用机制在基础层面上已有了解，但其与皮下免疫疗法中所见的免疫变化似乎存在相似之处。更好地理解这一机制应有助于开发更有效的治疗方案，并扩大这种免疫疗法的潜在应用范围。本文综述讨论了舌下免疫疗法可能的作用机制，包括来自动物和临床研究的数据，同时将其与目前对皮下免疫疗法的理解进行比较。
