Oztürk Emel, Yeşilova Zeki, Ilgan Seyfettin, Ozgüven Mehmet, Dağalp Kemal
Department of Nuclear Medicine, Ufuk University Medical School, Gülhane Military Medical Academy and Medical School, Ankara, Turkey.
J Gastroenterol Hepatol. 2009 Jul;24(7):1248-51. doi: 10.1111/j.1440-1746.2009.05845.x. Epub 2009 Apr 13.
Urea breath test (UBT) results could be false negative in patients taking antisecretory drugs. This effect would be prevented by citric acid administration during UBT. We prospectively investigated whether acidified 14C-urea capsule prevents false negative UBT results in patients taking antisecretory drugs and show interference with the duration of medications.
Sixty Helicobacter pylori positive patients were included. Pantoprazole (40 mg/day) was given to 27 patients for 28 days and ranitidine (300 mg. o.d.) to 33 patients for 60 days. Urea breath tests were repeated on days 14 and 28 in both groups and on day 60 in the ranitidine group.
The baseline mean breath counts of two groups did not show any significant difference. Pantoprazole led to a significant decrease in mean breath counts on day 14 (P < 0.005). Six of 27 and 3 of 25 patients taking pantoprazole developed negative or equivocal UBT results on days 14 and 28, respectively. Two of 32, 2 of 32 and 3 of 21 patients taking ranitidine developed negative or equivocal UBT results on days 14, 28 and 60, respectively.
The use of acidified 14C-urea capsule did not prevent false negative UBT results in patients taking pantoprazole and ranitidine, and the duration of medication does not affect the test results.
服用抗分泌药物的患者尿素呼气试验（UBT）结果可能出现假阴性。在UBT期间给予柠檬酸可防止这种影响。我们前瞻性地研究了酸化14C尿素胶囊是否能防止服用抗分泌药物患者的UBT结果出现假阴性，并观察其对用药持续时间的干扰。
纳入60例幽门螺杆菌阳性患者。27例患者给予泮托拉唑（40mg/天），持续28天；33例患者给予雷尼替丁（300mg，每日一次），持续60天。两组患者在第14天和第28天重复进行尿素呼气试验，雷尼替丁组在第60天重复进行。
两组的基线平均呼气计数无显著差异。泮托拉唑导致第14天平均呼气计数显著下降（P<0.005）。服用泮托拉唑的27例患者中，分别有6例和3例在第14天和第28天出现UBT结果阴性或不确定。服用雷尼替丁的32例患者中，分别有2例、2例和3例在第14天、第28天和第60天出现UBT结果阴性或不确定。
使用酸化14C尿素胶囊不能防止服用泮托拉唑和雷尼替丁患者的UBT结果出现假阴性，且用药持续时间不影响检测结果。
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