改良试验采用新的试验餐和 C-尿素呼气试验，用于质子泵抑制剂治疗的阳性和阴性消化不良患者。
Modified test using a new test meal and a C-urea breath test in positive and negative dyspepsia patients on proton pump inhibitors.
机构信息
AM DC Rogaška, Prvomajska 29 A, 3250 Rogaška Slatina, Slovenia.
Universitätsklinikum Magdeburg A. ö. R Klinik für Gastroenterologie, Hepatologie und Infektiologie, 39120 Magdeburg, Germany.
出版信息
World J Gastroenterol. 2017 Aug 28;23(32):5954-5961. doi: 10.3748/wjg.v23.i32.5954.
AIM
To determine the sensitivity and specificity of the C-urea breath test (UBT) in patients taking proton pump inhibitors (PPIs), using a new test meal Refex.
METHODS
One hundred and fourteen consecutive patients with dyspepsia, 53 () positive, 49 negative, were included in the study. The patients were then given esomeprazole 40 mg for 29 consecutive days, and the C-UBT with the new test meal was performed the next morning.
RESULTS
The sensitivity of the C-UBT with a cut off 2.5‰ was 92.45% (95%CI: 81.79%-97.91%) by per-protocol (PP) analysis and 78.13% (95%CI: 66.03%-87.49%) by intention-to-treat (ITT) analysis. The specificity of the C-UBT test was 96.00% in the ITT population (95%CI: 86.29%-99.51%) and 97.96% in the PP population (95%CI: 89.15%-99.95%).
CONCLUSION
The new test meal based C-UBT is highly accurate in patients on PPIs and can be used in those unable to stop their PPI treatment.
目的
使用新的测试餐 Refex，确定接受质子泵抑制剂（PPIs）治疗的患者中 C-尿素呼气试验（UBT）的灵敏度和特异性。
方法
纳入 114 例连续消化不良患者，其中 53 例（）阳性，49 例（）阴性。随后，这些患者连续 29 天服用埃索美拉唑 40mg，并于次日清晨进行 C-UBT 检查，采用新的测试餐。
结果
根据方案（PP）分析，以截断值 2.5‰为界，C-UBT 的灵敏度为 92.45%（95%CI：81.79%-97.91%），意向治疗（ITT）分析的灵敏度为 78.13%（95%CI：66.03%-87.49%）。在 ITT 人群中，C-UBT 检测的特异性为 96.00%（95%CI：86.29%-99.51%），在 PP 人群中为 97.96%（95%CI：89.15%-99.95%）。
结论
对于接受 PPI 治疗的患者，新的测试餐基于 C-UBT 具有很高的准确性，可用于无法停止 PPI 治疗的患者。
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