Lucchina Stefano, Parvex Sandra Leoni, Biegger Paul, Fusetti Cesare
Hand Surgery Unit, Surgical Department, Locarno's Regional Hospital, Via all'Ospedale 1 6600, Locarno, Switzerland.
Chin J Traumatol. 2009 Jun;12(3):181-3.
Pyoderma gangrenosum (PG) is a cutaneous ulcer developing so rapidly that may mimic a fulminating infection. The correct treatment is nonsurgical, and surgery may get the condition worse.1 FK-506 ointment (0.1% Protopic, Astellas Pharma AG, Fribourg) is usually indicated for inflammatory skin diseases, such as atopic dermatitis and psoriasis2 or for acute rejection reversal of human hand transplantation 3. A few reports of PG affecting the functions of hands can be found in the scientific literature and this report describes the first case treated by FK-506 ointment as an adjuvant therapy.
坏疽性脓皮病（PG）是一种发展迅速的皮肤溃疡，可能类似暴发性感染。正确的治疗方法是非手术治疗，手术可能会使病情恶化。1 FK-506软膏（0.1%的普特彼，安斯泰来制药公司，弗里堡）通常用于治疗炎症性皮肤病，如特应性皮炎和银屑病2，或用于逆转人类手部移植的急性排斥反应3。科学文献中可以找到一些关于PG影响手部功能的报道，本报告描述了首例使用FK-506软膏作为辅助治疗的病例。
