Department of Clinical Sciences of Companion Animals, Veterinary Faculty, Utrecht University, P.O. Box 80.154, 3508 TD Utrecht, The Netherlands.
Vet J. 2010 Aug;185(2):163-8. doi: 10.1016/j.tvjl.2009.05.009. Epub 2009 May 31.
Liver disease has been associated with abnormalities in haemostasis. In this study, coagulation times, platelet counts, platelet activity parameters, activities of individual coagulation factors, D-dimers, antithrombin (AT) and protein C activity were measured in 42 dogs with histologically confirmed liver disease. Outcome was correlated with histological diagnosis. One or more coagulation abnormalities were present in 57% of dogs with hepatic disease. Activated partial thromboplastin time was significantly prolonged in dogs with chronic hepatitis (CH), with or without cirrhosis. Mean platelet numbers, AT and factor IX activity were significantly lower in dogs with CH plus cirrhosis, compared to dogs with other hepatopathies. D-dimers were not significantly increased in any group. Only three dogs, all with different histological diagnoses, satisfied the criteria for disseminated intravascular coagulation (DIC). Haemostatic abnormalities were primarily seen in dogs with cirrhosis and this may be due to reduced synthesis rather than increased consumption of coagulation factors.
肝脏疾病与止血功能异常有关。在这项研究中，我们测量了 42 只经组织学证实患有肝脏疾病的狗的凝血时间、血小板计数、血小板活性参数、单个凝血因子活性、D-二聚体、抗凝血酶 (AT) 和蛋白 C 活性。结果与组织学诊断相关。57%患有肝脏疾病的狗存在一种或多种凝血异常。患有慢性肝炎 (CH) 伴或不伴肝硬化的狗的活化部分凝血活酶时间明显延长。与患有其他肝病的狗相比，患有 CH 加肝硬化的狗的平均血小板数、AT 和因子 IX 活性明显降低。D-二聚体在任何组中均未显著增加。只有 3 只狗，均有不同的组织学诊断，符合弥散性血管内凝血 (DIC) 的标准。止血异常主要见于肝硬化的狗，这可能是由于凝血因子合成减少而不是消耗增加所致。
