Horsley Valerie
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06522, USA.
J Cell Biol. 2009 Jun 1;185(5):761-3. doi: 10.1083/jcb.200904125.
Stem cells use both transcriptional and epigenetic mechanisms to control gene expression and regulate tissue development and homeostasis. In this issue, Gu et al. (Gu, B., P. Sun, Y. Yuan, R.C. Moraes, A. Li, A. Teng, A. Agrawal, C. Rhéaume, V. Bilanchone, J.M. Veltmaat, et al. 2009. J. Cell Biol. 185:811-826) reveal an important link between these two mechanisms in mammary epithelial stem cells by showing that transcriptional activation of beta-catenin downstream of Wnt signaling can be regulated epigenetically through a chromatin remodeling factor, Pygo2.
干细胞利用转录和表观遗传机制来控制基因表达，并调节组织发育和体内平衡。在本期杂志中，顾等人（顾，B.，孙，P.，袁，Y.，莫雷斯，R.C.，李，A.，滕，A.，阿格拉瓦尔，A.，雷奥姆，C.，比兰乔内，V.，韦尔特马特，J.M.等，2009年。《细胞生物学杂志》185:811 - 826）通过研究表明，Wnt信号下游β-连环蛋白的转录激活可通过染色质重塑因子Pygo2进行表观遗传调控，从而揭示了乳腺上皮干细胞中这两种机制之间的重要联系。
