细胞核RNA聚合酶介导的转录终止
Transcription termination by nuclear RNA polymerases.
作者信息
Richard Patricia, Manley James L
机构信息
Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
出版信息
Genes Dev. 2009 Jun 1;23(11):1247-69. doi: 10.1101/gad.1792809.
Abstract
Gene transcription in the cell nucleus is a complex and highly regulated process. Transcription in eukaryotes requires three distinct RNA polymerases, each of which employs its own mechanisms for initiation, elongation, and termination. Termination mechanisms vary considerably, ranging from relatively simple to exceptionally complex. In this review, we describe the present state of knowledge on how each of the three RNA polymerases terminates and how mechanisms are conserved, or vary, from yeast to human.
摘要
细胞核中的基因转录是一个复杂且受到高度调控的过程。真核生物中的转录需要三种不同的RNA聚合酶，每种聚合酶都有其自身的起始、延伸和终止机制。终止机制差异很大，从相对简单到极其复杂不等。在本综述中，我们描述了关于三种RNA聚合酶各自如何终止以及从酵母到人类这些机制是如何保守或变化的当前知识状态。
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