Phelan Suzanne, Kanaya Alka M, Subak Leslee L, Hogan Patricia E, Espeland Mark A, Wing Rena R, Burgio Kathryn L, Dilillo Vicki, Gorin Amy A, West Delia S, Brown Jeanette S
Kinesiology Department, California Polytechnic State University, San Luis Obispo, California, USA.
Diabetes Care. 2009 Aug;32(8):1391-7. doi: 10.2337/dc09-0516. Epub 2009 Jun 1.
OBJECTIVE To determine the prevalence and risk factors for urinary incontinence among different racial/ethnic groups of overweight and obese women with type 2 diabetes. RESEARCH DESIGN AND METHODS Cross-sectional analysis of baseline data from the Action for Health in Diabetes (Look AHEAD) study, a randomized clinical trial with 2,994 overweight/obese women with type 2 diabetes. RESULTS Weekly incontinence (27%) was reported more often than other diabetes-associated complications, including retinopathy (7.5%), microalbuminuria (2.2%), and neuropathy (1.5%). The prevalence of weekly incontinence was highest among non-Hispanic whites (32%) and lowest among African Americans (18%), and Asians (12%) (P < 0.001). Asian and African American women had lower odds of weekly incontinence compared with non-Hispanic whites (75 and 55% lower, respectively; P < 0.001). Women with a BMI of > or =35 kg/m(2) had a higher odds of overall and stress incontinence (55-85% higher; P < 0.03) compared with that for nonobese women. Risk factors for overall incontinence, as well as for stress and urgency incontinence, included prior hysterectomy (40-80% increased risk; P < 0.01) and urinary tract infection in the prior year (55-90% increased risk; P < 0.001). CONCLUSIONS Among overweight and obese women with type 2 diabetes, urinary incontinence is highly prevalent and far exceeds the prevalence of other diabetes complications. Racial/ethnic differences in incontinence prevalence are similar to those in women without diabetes, affecting non-Hispanic whites more than Asians and African Americans. Increasing obesity (BMI > or =35 kg/m(2)) was the strongest modifiable risk factor for overall incontinence and stress incontinence in this diverse cohort.
目的 确定不同种族/族裔的超重和肥胖2型糖尿病女性尿失禁的患病率及危险因素。研究设计与方法 对糖尿病健康行动(Look AHEAD)研究的基线数据进行横断面分析,该研究是一项针对2994名超重/肥胖2型糖尿病女性的随机临床试验。结果 每周尿失禁(27%)的报告率高于其他糖尿病相关并发症,包括视网膜病变(7.5%)、微量白蛋白尿(2.2%)和神经病变(1.5%)。每周尿失禁的患病率在非西班牙裔白人中最高(32%),在非裔美国人(18%)和亚洲人(12%)中最低(P<0.001)。与非西班牙裔白人相比,亚洲和非裔美国女性每周尿失禁的几率较低(分别低75%和55%;P<0.001)。与非肥胖女性相比,体重指数(BMI)≥35kg/m²的女性总体和压力性尿失禁的几率更高(高55 - 85%;P<0.03)。总体尿失禁以及压力性和急迫性尿失禁的危险因素包括既往子宫切除术(风险增加40 - 80%;P<0.01)和前一年的尿路感染(风险增加55 - 90%;P<0.001)。结论 在超重和肥胖的2型糖尿病女性中,尿失禁非常普遍,且远远超过其他糖尿病并发症的患病率。尿失禁患病率的种族/族裔差异与非糖尿病女性相似,对非西班牙裔白人的影响大于亚洲人和非裔美国人。在这个多样化的队列中,肥胖程度增加(BMI≥35kg/m²)是总体尿失禁和压力性尿失禁最强的可改变危险因素。