Department of Endocrinology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Urology, Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.
Int J Clin Pract. 2019 Nov;73(11):e13395. doi: 10.1111/ijcp.13395. Epub 2019 Aug 9.
To investigate the risk factors specific to diabetes mellitus that influence the progression of overactive bladder in Chinese population.
A total of 457 patients who were diagnosed with overactive bladder and diabetes mellitus at the Department of Endocrinology and Urinary Surgery Center of Zhejiang University Jinhua Hospital were enrolled from July 2015 to July 2018. Patients were assessed using a questionnaire and then divided into two groups according to the severity score: mild overactive bladder group and the moderate-severe overactive bladder group. Logistic analysis was performed to evaluate the risk factors associated with the progression of overactive bladder in diabetic patients.
Among the 457 patients with diabetes mellitus and overactive bladder, there was a significant difference in the severity of overactive bladder, age, diabetes duration, symptomatic diabetic peripheral neuropathy as well as ankle reflex (P < .05) between the two groups. Moreover, multivariate analysis revealed that age (OR: 1.59, P = .036), duration of diabetes (OR: 1.41, P = .049) and symptomatic diabetic peripheral neuropathy (OR: 2.39, P = .012) were independent risk factors for the progression of overactive bladder.
In Chinese diabetic patients, overactive bladder progression is closely related with the severity of diabetes mellitus. Age, diabetic duration and symptomatic diabetic peripheral neuropathy are independent predictors of the severity of overactive bladder. Patients with symptomatic diabetic peripheral neuropathy are at risk of overactive bladder.
探讨中国人群中糖尿病特有的影响膀胱过度活动症进展的危险因素。
2015 年 7 月至 2018 年 7 月，共纳入 457 例在浙江大学金华医院内分泌科和尿外科中心诊断为膀胱过度活动症和糖尿病的患者。患者通过问卷调查进行评估，然后根据严重程度评分分为两组：轻度膀胱过度活动症组和中重度膀胱过度活动症组。采用 Logistic 分析评估与糖尿病患者膀胱过度活动症进展相关的危险因素。
在 457 例患有糖尿病和膀胱过度活动症的患者中，两组间膀胱过度活动症严重程度、年龄、糖尿病病程、有症状的糖尿病周围神经病变和踝反射有显著差异（P<.05）。此外，多因素分析显示年龄（OR：1.59，P=.036）、糖尿病病程（OR：1.41，P=.049）和有症状的糖尿病周围神经病变（OR：2.39，P=.012）是膀胱过度活动症进展的独立危险因素。
在中国糖尿病患者中，膀胱过度活动症的进展与糖尿病的严重程度密切相关。年龄、糖尿病病程和有症状的糖尿病周围神经病变是膀胱过度活动症严重程度的独立预测因素。有症状的糖尿病周围神经病变的患者有发生膀胱过度活动症的风险。
