Loyola University Chicago, Health Sciences Campus, Maywood, IL, United States of America.
Loyola University Chicago, Health Sciences Campus, Maywood, IL, United States of America.
J Diabetes Complications. 2020 Jun;34(6):107561. doi: 10.1016/j.jdiacomp.2020.107561. Epub 2020 Mar 3.
The urinary microbiota in women with type 2 diabetes (T2DM) can have bacterial uropathogens which are more virulent. The primary objective was to describe and compare the characteristics of the microbiota in voided urine of women with and without T2DM.
Two cohorts of women: those with T2DM (n = 87) and those without T2DM (n = 49) were studied. Demographic data, hemoglobin A1c (HbA1c), fasting serum glucose, and voided urine were collected. To determine the characteristics of the microbiota in the urine, 16S rRNA gene sequencing was used.
The genus Lactobacillus was more often present in women with T2DM (75.9%, n = 66) than in the controls (59.2%, n = 30) (p = 0.042), as was the family Enterobacteriaceae (12.6% T2DM versus 2.0% control, p = 0.055). There was evidence of an association between HbA1c and the relative abundance of the various bacteria in the total cohort. The relative abundance of Lactobacillus was positively associated (ρ = 0.19, 95% CI: 0.02, 0.34), while Corynebacterium (ρ = -0.26, 95% CI: -0.41, -0.10) and Prevotella (ρ = -0.23, 95% CI: -0.38, -0.06) were inversely associated with HbA1c.
Enterobacteriaceae (e.g. E. coli) predispose women to urinary tract infections and since T2DM increases this risk, further study is needed. The species of Lactobacillus and its impact needs exploration.
患有 2 型糖尿病（T2DM）的女性的尿微生物群可能存在更具毒力的细菌尿路病原体。主要目的是描述和比较患有和不患有 T2DM 的女性的尿液微生物群的特征。
研究了两组女性：患有 T2DM（n=87）和不患有 T2DM（n=49）的女性。收集了人口统计学数据、糖化血红蛋白（HbA1c）、空腹血清葡萄糖和尿液。为了确定尿液中微生物群的特征，使用了 16S rRNA 基因测序。
与对照组（59.2%，n=30）相比，T2DM 患者（75.9%，n=66）中更常存在乳杆菌属（p=0.042），肠杆菌科（12.6%T2DM 与 2.0%对照组，p=0.055）。在整个队列中，有证据表明 HbA1c 与各种细菌的相对丰度之间存在关联。乳杆菌属的相对丰度呈正相关（ρ=0.19，95%置信区间：0.02，0.34），而棒状杆菌属（ρ=-0.26，95%置信区间：-0.41，-0.10）和普雷沃氏菌属（ρ=-0.23，95%置信区间：-0.38，-0.06）与 HbA1c 呈负相关。
肠杆菌科（例如大肠杆菌）使女性易患尿路感染，而 T2DM 会增加这种风险，因此需要进一步研究。需要探索乳杆菌属的种类及其影响。
