Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070 Würzburg, Germany.
Clin Oral Investig. 2010 Jun;14(3):291-6. doi: 10.1007/s00784-009-0292-2. Epub 2009 Jun 2.
MAGE-A antigens are only expressed on tumor cells. The aim of this study was to identify their expression in patients with oral squamous cell carcinoma (OSCC). Forty-seven patients with primary OSCC was selected retrospectively. Histo-pathological sections were stained immunohistochemically with MAGE-A antibody 57B. The results were evaluated regarding tumor size (T), lymph-node metastasis (N), blood vessel infiltration (V), lymph vessel infiltration (L), grading (G), and sex. MAGE-A antigens were expressed in 55% of all patients. Expression increased with tumor size (T1 = 56%; T2 = 44%; T3 = 67%; T4 = 71%). Lymph-node metastasis had no influence (N0 and N1 about 50%). Tumors with blood and lymph vessel infiltration had higher expression (V0 = 50%; V1 = 100%; L0 = 46%; L1 = 71%). Less-differentiated tumors showed higher rates (G1 = 50%; G2 = 45%; G3 = 83%). OSCC in men were positive in 62% and in women in 38%. MAGE-A antigens are frequently expressed in OSCC. Their expression seems to increase with tumor dedifferentiation.
MAGE-A 抗原仅在肿瘤细胞上表达。本研究旨在确定其在口腔鳞状细胞癌（OSCC）患者中的表达。回顾性选择了 47 名原发性 OSCC 患者。组织病理学切片用 MAGE-A 抗体 57B 进行免疫组织化学染色。评估结果与肿瘤大小（T）、淋巴结转移（N）、血管浸润（V）、淋巴管浸润（L）、分级（G）和性别有关。所有患者中，MAGE-A 抗原的表达率为 55%。表达随肿瘤大小增加（T1=56%；T2=44%；T3=67%；T4=71%）。淋巴结转移无影响（N0 和 N1 约为 50%）。有血管和淋巴管浸润的肿瘤表达率更高（V0=50%；V1=100%；L0=46%；L1=71%）。低分化肿瘤的表达率更高（G1=50%；G2=45%；G3=83%）。男性 OSCC 的阳性率为 62%，女性为 38%。MAGE-A 抗原在 OSCC 中常表达。其表达似乎随肿瘤去分化程度增加而增加。
