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MAGE-A作为提高口腔鳞状细胞癌诊断准确性的新方法：病例报告

MAGE-A as a novel approach in the diagnostic accuracy of oral squamous cell cancer: a case report.

作者信息

Metzler Philipp, Mollaoglu Nur, Schwarz Stephan, Neukam Friedrich W, Nkenke Emeka, Ries Jutta

机构信息

Department of Craniomaxillofacial and Oral Surgery, University of Zurich, Frauenklinikstrasse 24, 8091 Zurich, Switzerland.

出版信息

Head Neck Oncol. 2009 Dec 16;1:39. doi: 10.1186/1758-3284-1-39.

DOI:10.1186/1758-3284-1-39
PMID:20015401
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2803165/
Abstract

BACKGROUND

The aim of this case report is to introduce the combined use of brush biopsy and measurement of MAGE-A expression in the diagnosis of oral squamous cell carcinoma (OSCC).

CASE REPORT

We report of a 49-year old male patient who was referred to our department with a persistent-suspicious looking leukoplakia. Brush biopsy and an incisional biopsy were performed following clinical diagnosis. Histopathological examination revealed no malignancy. Expression analysis of melanoma-associated antigens A (MAGE-A) using real time RT-PCR was applied to brush biopsy materials because of the high prevalence of MAGE-A determined previously in OSCC's. Results indicated significant MAGE-A3 and A4 expression pattern. Therefore, the lesion was excised completely and an early invasive carcinoma was identified.

CONCLUSION

These results emphasize the role of brush biopsy using a tumor marker with a high expression frequency combined with a high sensitive and high specific detection system in the early diagnosis of OSCC, particularly in widespread leukoplakias.

摘要

背景

本病例报告的目的是介绍刷检活检联合MAGE - A表达检测在口腔鳞状细胞癌（OSCC）诊断中的应用。

病例报告

我们报告了一名49岁男性患者，因持续存在可疑的白斑被转诊至我科。临床诊断后进行了刷检活检和切开活检。组织病理学检查未发现恶性病变。由于先前在OSCC中确定的MAGE - A高表达率，对刷检活检材料进行了使用实时RT - PCR的黑色素瘤相关抗原A（MAGE - A）表达分析。结果显示MAGE - A3和A4有显著表达模式。因此，将病变完全切除，确诊为早期浸润性癌。

结论

这些结果强调了使用高表达频率的肿瘤标志物联合高灵敏、高特异性检测系统的刷检活检在OSCC早期诊断中的作用，特别是在广泛的白斑病中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9b5/2803165/a24190ba1285/1758-3284-1-39-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9b5/2803165/04186dfedba4/1758-3284-1-39-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9b5/2803165/a3a0ca1e71aa/1758-3284-1-39-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9b5/2803165/7f5cbdd745ad/1758-3284-1-39-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9b5/2803165/df971a97cbb6/1758-3284-1-39-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9b5/2803165/ce2048e78a41/1758-3284-1-39-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9b5/2803165/a24190ba1285/1758-3284-1-39-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9b5/2803165/04186dfedba4/1758-3284-1-39-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9b5/2803165/a3a0ca1e71aa/1758-3284-1-39-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9b5/2803165/7f5cbdd745ad/1758-3284-1-39-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9b5/2803165/df971a97cbb6/1758-3284-1-39-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9b5/2803165/ce2048e78a41/1758-3284-1-39-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9b5/2803165/a24190ba1285/1758-3284-1-39-6.jpg

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