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Mechanisms of therapeutic effects of granulocytic colony-stimulating factor in experimental diabetes mellitus.

作者信息

Gol'dberg E D, Dygai A M, Zhdanov V V, Zyuz'kov G N, Ermakova N N, Vetoshkina T V, Fomina T I, Ermolaeva L A, Dubskaya T Yu

机构信息

Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia.

出版信息

Bull Exp Biol Med. 2008 Oct;146(4):543-6. doi: 10.1007/s10517-009-0319-3.

DOI:10.1007/s10517-009-0319-3
PMID:19489338
Abstract

We studied the mechanisms of therapeutic effects of granulocytic colony-stimulating factor in experimental diabetes mellitus. It was found that this preparation increased the number of mesenchymal precursor cells in the bone marrow and peripheral blood with subsequent increase in the content of progenitor cells in the pancreas. These results attest to mobilization of mesenchymal progenitor cells and their migration into the damaged tissue accompanied by morphofunctional recovery of the insulin-producing apparatus.

摘要

相似文献

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Specific activity of electron-beam synthesis immobilized hyaluronidase on G-CSF induced mobilization of bone marrow progenitor cells.电子束合成固定化透明质酸酶对 G-CSF 诱导的骨髓祖细胞动员的比活度。
Stem Cell Rev Rep. 2013 Apr;9(2):140-7. doi: 10.1007/s12015-012-9423-2.