Preventive Cardiology, Sterling Rock Falls Clinic, Ltd, Sterling, IL 61081, USA.
Int J Clin Pract. 2009 Jun;63(6):903-11. doi: 10.1111/j.1742-1241.2009.02053.x.
Achieving adequate control of cardiovascular risk in type 2 diabetes mellitus (DM) is crucially important; however, the atherogenic dyslipidaemia (including low high-density lipoprotein cholesterol and hypertriglyceridaemia) typically encountered in type 2 DM is often managed inadequately. Evidence from the Fenofibrate Intervention and Event Lowering in Diabetes study suggests that fenofibrate reduces the risk of long-term macrovascular and microvascular type 2 diabetic complications, especially in patients demonstrating features of the metabolic syndrome. Fenofibrate represents a useful treatment option for controlling cardiovascular risk in type 2 diabetes patients in the community setting.
实现 2 型糖尿病(DM)患者心血管风险的充分控制至关重要;然而,2 型 DM 中常见的动脉粥样硬化性血脂异常(包括低高密度脂蛋白胆固醇和高三酰甘油血症)往往管理不当。来自非诺贝特干预和糖尿病事件降低研究的证据表明,非诺贝特降低了长期大血管和微血管 2 型糖尿病并发症的风险,尤其是在具有代谢综合征特征的患者中。非诺贝特是控制社区环境中 2 型糖尿病患者心血管风险的一种有用的治疗选择。