Kirdani R, Barua N R, Sandberg A A
J Clin Endocrinol Metab. 1977 Jun;44(6):1121-29. doi: 10.1210/jcem-44-6-1121.
The present study was conducted in order to ascertain whether the human kidney can conjugate androgens to an extent similar to that of estriol (E3). Differently labeled androgens (testosterone, DHT and androstenedione) were injected simultaneously into a peripheral vein and the renal artery. The excretion of the radioactivity in the early urine collections served as an index of the ability of the kidney to conjugate and/or metabolize the various steroids administered. It was shown that the human kidney can conjugate testosterone to some extent as the 17-glucuronide of DHT, but to a much lesser degree that E3. Androstenedione was not conjugated by the kidney and the excretion DHT was paradoxically lower following its renal artery administration than following its peripheral injection. We interpret the latter to indicate that some kidney cells may contain receptors with very high affinity for DHT, thus leading to the lower excretion observed. The administration of androstenediol (into the renal artery) and E3 (peripherally) indicated that the diol was not conjugated as readily as E3. The results point to the ability of the kidney to conjugate testosterone to some extent; however, in no case was it able to conjugate an androgen with the same facility as it does E3.
本研究旨在确定人类肾脏结合雄激素的程度是否与雌三醇（E3）相似。将不同标记的雄激素（睾酮、双氢睾酮和雄烯二酮）同时注入外周静脉和肾动脉。早期尿液收集物中的放射性排泄作为肾脏结合和/或代谢所给予的各种类固醇能力的指标。结果表明，人类肾脏能够在一定程度上结合睾酮生成双氢睾酮的17-葡萄糖醛酸苷，但程度远低于E3。肾脏不能结合雄烯二酮，并且肾动脉注射双氢睾酮后的排泄量反而比外周注射后的排泄量低。我们认为后者表明某些肾细胞可能含有对双氢睾酮具有非常高亲和力的受体，从而导致观察到较低的排泄量。（肾动脉）注射雄烯二醇和（外周）注射E3表明，二醇不如E3那样容易被结合。结果表明肾脏有一定程度结合睾酮的能力；然而，在任何情况下，它结合雄激素的能力都不如结合E3那样容易。
