Reisz Julie A, Klorig Erika B, Wright Marcus W, King S Bruce
Department of Chemistry, Salem Hall, Box 7486, Wake Forest University, Winston-Salem, North Carolina 27109, USA.
Org Lett. 2009 Jul 2;11(13):2719-21. doi: 10.1021/ol900914s.
Nitroxyl (HNO) demonstrates a unique chemical and biological profile compared to nitric oxide (NO). Phosphorus NMR studies reveal that HNO reacts with triarylphosphines to give the corresponding phosphine oxide and aza-ylide. In the presence of a properly situated electrophilic ester, the aza-ylide undergoes a Staudinger ligation to yield an amide with the nitrogen atom being derived from HNO. These results define new HNO reactivity and provide the basis of new HNO detection methods.
与一氧化氮（NO）相比，硝酰（HNO）具有独特的化学和生物学特性。磷核磁共振研究表明，HNO与三芳基膦反应生成相应的氧化膦和氮杂叶立德。在适当位置的亲电酯存在下，氮杂叶立德会发生施陶丁格连接反应，生成一种酰胺，其中氮原子源自HNO。这些结果定义了新的HNO反应活性，并为新的HNO检测方法提供了基础。
