Isik S Rana, Karakaya Gul, Celikel Serhart, Demir Ahmet U, Kalyoncu A Fuat
Department of Chest Diseases, Adult Allergy Unit, Hacettepe University School of Medicine, Ankara, Turkey.
Int Arch Allergy Immunol. 2009;150(3):299-306. doi: 10.1159/000222683. Epub 2009 Jun 4.
The coexistence of allergic diseases and chronic urticaria (CU) is not uncommon. Our aim was to show the prevalence of allergic diseases in chronic urticaria patients and whether possible risk factors precipitate the development of these conditions.
The data of 953 patients diagnosed with CU in our adult allergy clinic between January 1991 and June 2006 were retrospectively evaluated.
The mean ages of the CU patients with and without non-steroidal anti-inflammatory drug hypersensitivity (NSAIDH) were 39.0 +/- 11.8 and 36.7+/- 12.3, respectively (p = 0.014). There was a female predominance in both groups (74.6 and 68.2%, respectively, p = 0.06). Apparently, some conditions occurred significantly more often in CU patients with NSAIDH compared to those without NSAIDH: 16.4 and 8.4% for asthma (p < 0.001), 4.2 and 0.8% for nasal polyps (p < 0.01), 20.8 and 7.3% for antibiotic hypersensitivity (p < 0.001), 21.6 and 12.3% for metal sensitization (p < 0.01), and 8 and 0.6% for familial NSAIDH (p < 0.001), respectively. Dermographism was more common in CU patients without NSAIDH compared to those with NSAIDH (29.4 and 21.2%, respectively; p < 0.05). NSAIDH increased the risk of asthma and rhinitis development [odds ratios: 52.9 (18.1-154.6) and 5.2 (2.0-13.4)].
Based on our data, the incidence rates of asthma, nasal polyps, antibiotic hypersensitivity, metal sensitization and familial NSAIDH are increased in patients with CU with NSAIDH compared to those with CU only. Coexistence of NSAIDH and CU increases the risk of developing asthma and rhinitis.
过敏性疾病与慢性荨麻疹（CU）并存并不罕见。我们的目的是揭示慢性荨麻疹患者中过敏性疾病的患病率，以及是否有潜在危险因素促使这些疾病的发生。
对1991年1月至2006年6月间在我们成人过敏门诊诊断为慢性荨麻疹的953例患者的数据进行回顾性评估。
有和没有非甾体抗炎药超敏反应（NSAIDH）的慢性荨麻疹患者的平均年龄分别为39.0±11.8岁和36.7±12.3岁（p = 0.014）。两组均以女性为主（分别为74.6%和68.2%，p = 0.06）。显然，与无NSAIDH的慢性荨麻疹患者相比，某些疾病在有NSAIDH的慢性荨麻疹患者中发生得更为频繁：哮喘分别为16.4%和8.4%（p < 0.001），鼻息肉分别为4.2%和0.8%（p < 0.01），抗生素超敏反应分别为20.8%和7.3%（p < 0.001），金属致敏分别为21.6%和12.3%（p < 0.01），家族性NSAIDH分别为8%和0.6%（p < 0.001）。与有NSAIDH的慢性荨麻疹患者相比，皮肤划痕症在无NSAIDH的慢性荨麻疹患者中更为常见（分别为29.4%和21.2%；p < 0.05）。NSAIDH增加了哮喘和鼻炎发生的风险[比值比：52.9（18.1 - 154.6）和5.2（2.0 - 13.4）]。
根据我们的数据，与仅患有慢性荨麻疹的患者相比，患有NSAIDH的慢性荨麻疹患者中哮喘、鼻息肉、抗生素超敏反应、金属致敏和家族性NSAIDH的发病率更高。NSAIDH与慢性荨麻疹并存会增加患哮喘和鼻炎的风险。
