Lee Hee Hwan, Lee Jong Seok, Cho Jae Youl, Kim Young Eon, Hong Eock Kee
Department of Bioengineering and Technology, Kangwon National University, Chuncheon 200-701, Korea.
J Microbiol Biotechnol. 2009 May;19(5):455-61. doi: 10.4014/jmb.0809.542.
There is a significant amount of experimental evidence suggesting that polysaccharides from mushrooms enhance the host immune system by activating various mechanisms in immune cells, including macrophages. In this study, polysaccharides from Lentinus edodes were found to stimulate the functional activation of macrophages to secrete inflammatory mediators and cytokines and increase the phagocytotic uptake. The chemical properties of the stimulatory polysaccharides, CPFN-G-I, CPBN-G, and CPBA-G, were determined based on their monosaccharide composition, which mainly consisted of glucose and mannose. According to FT-IR and GC/MS, the structure of CPFN-G-I, purified from the fruiting body of L. edodes, was found to consist of a beta-1,6-branched-beta-1,4-glucan, whereas CPBN-G and CPBA-G, purified from the liquid.
有大量实验证据表明，蘑菇中的多糖可通过激活免疫细胞（包括巨噬细胞）中的各种机制来增强宿主免疫系统。在本研究中，发现香菇多糖能刺激巨噬细胞的功能激活，使其分泌炎症介质和细胞因子，并增加吞噬摄取。基于其主要由葡萄糖和甘露糖组成的单糖组成，确定了刺激性多糖CPFN-G-I、CPBN-G和CPBA-G的化学性质。根据傅里叶变换红外光谱（FT-IR）和气相色谱-质谱联用（GC/MS）分析，从香菇子实体中纯化得到的CPFN-G-I的结构由β-1,6-分支-β-1,4-葡聚糖组成，而从液体中纯化得到的CPBN-G和CPBA-G……（原文此处不完整）
