秀丽锦龟对甲氧苄啶的N-氧化、O-去甲基化及排泄作用
N-oxidation, O-demethylation, and excretion of trimethoprim by the turtle Pseudemys scripta elegans.
作者信息
Vree T B, Vree J B, Kolmer E B, Hekster Y A, Nouws J F, Shimoda M
机构信息
Department of Clinical Pharmacy, Sint Radboud University Hospital, Nijmegen, The Netherlands.
出版信息
Vet Q. 1989 Apr;11(2):125-8. doi: 10.1080/01652176.1989.9694209.
PMID:2741295
Abstract
Trimethoprim was excreted within one hour after being given orally to the turtle Pseudemys scripta elegans. No O-demethylated or N-oxide metabolites were detected.
摘要
给秀丽锦龟口服甲氧苄啶后，该药在1小时内排出。未检测到O-去甲基化或N-氧化物代谢物。
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