中央无形体和边缘无形体之间共同的免疫显性多肽的鉴定。

Identification of immunodominant polypeptides common between Anaplasma centrale and Anaplasma marginale.

作者信息

Shkap V, Pipano E, McGuire T C, Palmer G H

机构信息

Department of Parasitology, Kimron Veterinary Institute, Bet Dagan, Israel.

出版信息

Vet Immunol Immunopathol. 1991 Aug;29(1-2):31-40. doi: 10.1016/0165-2427(91)90050-m.

DOI:10.1016/0165-2427(91)90050-m

PMID:1949581

Abstract

High titered antibody from rabbits immunized with Anaplasma centrale or from cattle recovered from A. centrale infection bound predominantly to several 33-36 kDa polypeptides present in both A. centrale and the Israel-NT isolate of Anaplasma marginale. High titered bovine antibody against the Israel-NT isolate of A. marginale also reacted predominantly with A. centrale polypeptides in this size range. The immunodominance of the 33-36 kDa polypeptides and their cross-reactivity indicate that these shared epitopes may be primarily responsible for the cross-protective immunity between A. centrale and A. marginale.

摘要

用中央无形体免疫的兔子或从中央无形体感染中恢复的牛产生的高滴度抗体，主要与中央无形体和边缘无形体以色列-NT分离株中均存在的几种33-36 kDa多肽结合。针对边缘无形体以色列-NT分离株的高滴度牛抗体在这个大小范围内也主要与中央无形体多肽发生反应。33-36 kDa多肽的免疫显性及其交叉反应表明，这些共享表位可能是中央无形体和边缘无形体之间交叉保护性免疫的主要原因。