Gao Zhanghua, Li Yingfa, Cooksey John P, Snaddon Thomas N, Schunk Stefan, Viseux Eddy M E, McAteer Stephen M, Kocienski Philip J
The School of Chemistry and The Institute of Process Research and Development, Leeds University, Leeds LS2 9 JT, UK.
Angew Chem Int Ed Engl. 2009;48(27):5022-5. doi: 10.1002/anie.200901608.
Caught in the middle: The ionomycin calcium complex (see structure; O red, Ca green) was the target of an approach featuring the efficient asymmetric synthesis of an allene by a copper(I)-mediated anti-selective S(N)2' reaction, a highly stereoselective gold(III)-catalyzed cycloisomerization of an alpha-hydroxyallene, and a Rh-catalyzed rearrangement of an alpha-diazo-beta-hydroxyketone.
离子霉素钙络合物（见结构；氧为红色，钙为绿色）是一种合成方法的目标，该方法包括通过铜（I）介导的反选择性S(N)2'反应高效不对称合成丙二烯、α-羟基丙二烯的高立体选择性金（III）催化环异构化以及铑催化的α-重氮-β-羟基酮重排。
