State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, PR China.
Biomaterials. 2010 Apr;31(12):3374-83. doi: 10.1016/j.biomaterials.2010.01.044. Epub 2010 Feb 1.
Multifunctional strontium hydroxyapatite (SrHAp) nanorods with luminescent and mesoporous properties have been successfully synthesized by a hydrothermal method. SEM and TEM images indicate that the mesoporous SrHAp samples consist of monodiperse nanorods with lengths of 120-150 nm, diameters of around 20 nm, and the mesopore size of 3-5 nm. The as-obtained SrHAp nanorods show an intense bright blue emission (centered at 432 nm, lifetime 11.6 ns, quantum efficiency: 22%), which might arise from CO(2)(*-) radical impurities in the crystal lattice under long-wavelength UV-light irradiation. Furthermore, the amount of trisodium citrate has an obvious impact on the particle size and the luminescence properties of the products, respectively. The drug storage/release test indicates that the luminescent SrHAp nanorods show a drug loading and controlled release properties for ibuprofen (IBU). Additionally, the emission intensity of SrHAp in the drug carrier system increases with the cumulative released amount of IBU, making the drug release might be easily tracked and monitored by the change of the luminescence intensity. This luminescent material may be potentially applied in the drug delivery and disease therapy fields.
多功能锶羟基磷灰石（SrHAp）纳米棒具有发光和介孔性能，已通过水热法成功合成。SEM 和 TEM 图像表明，介孔 SrHAp 样品由单分散纳米棒组成，长度为 120-150nm，直径约为 20nm，介孔尺寸为 3-5nm。所获得的 SrHAp 纳米棒在长波长紫外光照射下显示出强烈的亮蓝色发射（中心在 432nm，寿命 11.6ns，量子效率：22%），这可能源于晶体格子中的 CO(2)(*-)自由基杂质。此外，三钠柠檬酸的用量分别对产物的粒径和发光性能有明显的影响。药物储存/释放测试表明，发光 SrHAp 纳米棒对布洛芬（IBU）具有药物负载和控制释放性能。此外，药物载体系统中 SrHAp 的发射强度随着 IBU 的累积释放量的增加而增加，使得药物释放可以通过发光强度的变化来轻松跟踪和监测。这种发光材料可能在药物输送和疾病治疗领域具有潜在的应用。
