通过三组分炔烃-亚胺复分解反应串联合成 2,3-二氢-4-亚氨基喹啉。
Tandem synthesis of 2,3-dihydro-4-iminoquinolines via three-component alkyne-imine metathesis.
机构信息
Laboratory of Organic Reaction Chemistry, Showa PharmaceuticalUniversity, 3-3165 Higashi-Tamagawagakuen,Machida, Tokyo 194-8543, Japan.
出版信息
J Org Chem. 2010 Oct 15;75(20):6980-2. doi: 10.1021/jo1013993.
PMID:20843018
Abstract
In the absence of any catalysts, ortho-alkynylanilines react with aldehydes and amines in HFIP to form trans-2,3-disubstituted 2,3-dihydro-4-iminoquinolines in a complete trans-selective manner via the three-component alkyne-imine metathesis.
摘要
在没有任何催化剂的情况下，邻炔基苯胺与醛和胺在 HFIP 中反应，通过三组分炔基亚胺复分解以完全反式选择性方式形成反式-2,3-二取代 2,3-二氢-4-亚氨基喹啉。
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