天然免疫系统对病毒DNA的细胞内感知。
Intracellular sensing of viral DNA by the innate immune system.
作者信息
Mansur Daniel S, Smith Geoffrey L, Ferguson Brian J
机构信息
Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Universidade Federal de Santa Catarina, Floraniopolis, Brazil.
Department of Pathology, Tennis Court Road, Cambridge, CB2 1QP, UK.
出版信息
Microbes Infect. 2014 Dec;16(12):1002-12. doi: 10.1016/j.micinf.2014.09.010. Epub 2014 Oct 12.
Recent years have seen a great advance in knowledge of how a host senses infection. Nucleic acids, as a common denominator to all pathogens, are at the centre of several of the sensing pathways, especially those involved with the recognition of viruses. In this review we discuss the current knowledge on how intracellular DNA is sensed by the mammalian host.
近年来，宿主感知感染的相关知识取得了巨大进展。核酸作为所有病原体的共同特征，处于多种感知途径的核心，尤其是那些与病毒识别有关的途径。在这篇综述中，我们讨论了目前关于哺乳动物宿主如何感知细胞内DNA的知识。
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