Eisenächer Katharina, Steinberg Christian, Reindl Wolfgang, Krug Anne
Department of Medicine II, Technical University, Ismaninger Str 22, D-81675, Munich, Germany.
Immunobiology. 2007;212(9-10):701-14. doi: 10.1016/j.imbio.2007.09.007. Epub 2007 Nov 9.
Dendritic cells which are located at the interface of innate and adaptive immunity are targets for infection by many different DNA and RNA viruses. Dendritic cell subpopulations express specific nucleic acid recognition receptors belonging to the Toll-like receptor family (TLR3, 7, 8, 9) and the cytosolic RNA helicase family (RIG-I, MDA5, LGP2). Activation of dendritic cells by viral DNA and RNA via these receptors is essential for triggering the innate antiviral immune response and shaping the ensuing adaptive antiviral immunity. This review will summarize our current knowledge of viral nucleic acid recognition and signaling by Toll-like receptors and RNA helicases focusing on recent evidence for their specific functions in antiviral defense in vivo.
位于固有免疫和适应性免疫界面的树突状细胞是许多不同DNA和RNA病毒的感染靶点。树突状细胞亚群表达属于Toll样受体家族（TLR3、7、8、9）和胞质RNA解旋酶家族（RIG-I、MDA5、LGP2）的特定核酸识别受体。病毒DNA和RNA通过这些受体激活树突状细胞对于触发固有抗病毒免疫反应和形成随后的适应性抗病毒免疫至关重要。本综述将总结我们目前关于Toll样受体和RNA解旋酶对病毒核酸的识别和信号传导的知识，重点关注它们在体内抗病毒防御中特定功能的最新证据。
