Cabrera-Gómez J A, Bonnan M, González-Quevedo A, Saiz-Hinarejos A, Marignier R, Olindo S, Graus F, Smadja D, Merle H, Thomas L, Gómez-García A, Cabre P
Cuban Multiple Sclerosis Society and International Neurological Restoration Center, Havana, Cuba.
Mult Scler. 2009 Jul;15(7):828-33. doi: 10.1177/1352458509104585. Epub 2009 Jun 4.
In Caucasian populations neuromyelitis optica (NMO-IgG) antibody has been detected in 27.1% / 78.2% of patients with relapsing-NMO (R-NMO). The prevalence reported for the disease in the Caribbean is 3.1/100,000 in the French West Indies (FWI) and 0.52 /100,000 in Cuba, but the NMO antibody status is unknown.
To assess the NMO-IgG antibody status of Cuban/FWI RNMO patients, comparing with European cases tested at the same laboratories.
Serum NMO-IgG antibodies were assayed in 48 R-NMO patients (Wingerchucks 1999 criteria): Cuba (24)/FWI (24), employing Lennon et aĺs method. We compared the demographic, clinical, disability and laboratory data between NMO-IgG +/- patients. All the data were reviewed and collected blinded to the NMO-IgG status.
Seropositivity of the NMO-IgG antibody demonstrated a lower rate in the Caribbean (33.3%), as compared with Caucasian patients from Spain/Italy (62.5%) and France (53.8%). Caribbean patients with NMO-IgG (+) displayed more attacks, more spinal attacks and a higher EDSS than NMO-IgG (-) cases, while brain and spinal cord MRI lesions were more frequent during remission, with more vertebral segments, more gray, white matter and holocord involvement.
NMO IgG positive antibodies in NMO patients had a lower rate in the Caribbean area - where the population has a predominant African ancestry - than in Caucasian Europeans, suggesting the influence of a possible ethnic factor in the pathogenesis of the disease, but they confer a worse course with more attacks, more disability and MRI lesions.
在高加索人群中，复发型视神经脊髓炎（R-NMO）患者中检测到视神经脊髓炎（NMO-IgG）抗体的比例为27.1%/78.2%。据报道，该疾病在加勒比地区的患病率为：法属西印度群岛（FWI）为3.1/100,000，古巴为0.52/100,000，但NMO抗体状态未知。
评估古巴/FWI地区R-NMO患者的NMO-IgG抗体状态，并与在同一实验室检测的欧洲病例进行比较。
采用Lennon等人的方法，对48例R-NMO患者（符合Wingerchucks 1999标准）进行血清NMO-IgG抗体检测：古巴（24例）/FWI（24例）。我们比较了NMO-IgG阳性/阴性患者的人口统计学、临床、残疾和实验室数据。所有数据均在对NMO-IgG状态不知情的情况下进行回顾和收集。
与来自西班牙/意大利（62.5%）和法国（53.8%）的高加索患者相比，加勒比地区NMO-IgG抗体的血清阳性率较低（33.3%）。与NMO-IgG阴性病例相比，NMO-IgG阳性的加勒比患者发作次数更多、脊髓发作更多且扩展残疾状态量表（EDSS）更高，而在缓解期脑和脊髓磁共振成像（MRI）病变更频繁，累及更多椎体节段、更多灰质、白质和全脊髓。
与欧洲白种人相比，在加勒比地区（该地区人群主要为非洲裔）NMO患者中NMO IgG阳性抗体的比例较低，这表明可能存在种族因素对该疾病发病机制的影响，但这些抗体导致病情更严重，发作更多、残疾更多且MRI病变更多。
