日本剥脱性产毒和不产毒猪葡萄球菌菌株的抗菌药敏性

Antimicrobial susceptibilities of exfoliative toxigenic and non-toxigenic Staphylococcus hyicus strains in Japan.

作者信息

Futagawa-Saito Keiko, Ba-Thein William, Fukuyasu Tsuguaki

机构信息

Department of Animal Health, Azabu University, Kanagawa, Japan.

出版信息

J Vet Med Sci. 2009 May;71(5):681-4. doi: 10.1292/jvms.71.681.

DOI:10.1292/jvms.71.681

PMID:19498301

Abstract

Staphylococcus hyicus isolates (n=207), including 150 exfolitative toxigenic and 57 non-toxigenic strains, were examined for their susceptibility to 13 antimicrobial agents by using the dehydrated 96-well MIC panel system. The frequency of their resistance to penicillin and ampicillin was 76.8% (159/207), followed by erythromycin (56%, 116/207), trimethoprim-sulfamethoxazole (28.5%, 59/207), chloramphenicol (24.2%, 50/207), kanamycin (19.8%, 41/207), and doxycycline (1.4%, 3/207). Resistance to chloramphenicol and trimethoprim-sulfamethoxazole was significantly higher in toxigenic strains than non-toxigenic strains (p<0.01), whereas kanamycin and erythromycin resistance was significantly higher in non-toxigenic strains (p<0.01 and <0.05, respectively). Resistance to two or more antimicrobials was observed in 85.5% (177/207) of total strains, with a significantly higher occurrence in toxigenic strains (89.3%, 134/150 vs. 75.4%, 43/57; p<0.05).

摘要

使用脱水96孔微量肉汤稀释板系统，检测了207株猪葡萄球菌分离株（其中150株产剥脱毒素，57株不产毒素）对13种抗菌药物的敏感性。它们对青霉素和氨苄西林的耐药率为76.8%（159/207），其次是红霉素（56%，116/207）、甲氧苄啶-磺胺甲恶唑（28.5%，59/207）、氯霉素（24.2%，50/207）、卡那霉素（19.8%，41/207）和强力霉素（1.4%，3/207）。产毒素菌株对氯霉素和甲氧苄啶-磺胺甲恶唑的耐药率显著高于不产毒素菌株（p<0.01），而不产毒素菌株对卡那霉素和红霉素的耐药率显著更高（分别为p<0.01和<0.05）。在85.5%（177/207）的菌株中观察到对两种或更多种抗菌药物耐药，产毒素菌株中的发生率显著更高（89.3%，134/150对75.4%，43/57；p<0.05）。