Thorley-Lawson D A, Chess L, Strominger J L
J Exp Med. 1977 Aug 1;146(2):495-508. doi: 10.1084/jem.146.2.495.
Studies have been performed on in vitro infection by Epstein-Barr virus (EBV) of subpopulations of human lymphocytes. B cells of adult peripheral or fetal cord blood transform with equal efficiency, whether assayed by DNA synthesis induction or by outgrowth of transformed lymphocytes. In contrast, unfractionated adult lymphocytes transform much less efficiently than those from fetal cord. Reconstitution experiments of different cell preparations indicated that this difference was due to a suppression of B-cell proliferation by adult Ig-negative lymphocytes which fetal Ig-negative lymphocytes were unable to perform. Separation of Ig-negative lymphocytes into various subpopulations revealed that the suppression was performed by T cells. Macrophages and null cells play little or no role in suppression. The relevance of this phenomenon to infection and recovery from EBV infection during and after infectious mononucleosis is discussed.
已经对爱泼斯坦-巴尔病毒（EBV）对人淋巴细胞亚群的体外感染进行了研究。无论通过DNA合成诱导测定还是通过转化淋巴细胞的生长来测定，成人外周血或胎儿脐带血的B细胞转化效率相同。相比之下，未分级的成人淋巴细胞转化效率比胎儿脐带血淋巴细胞低得多。不同细胞制剂的重建实验表明，这种差异是由于成人Ig阴性淋巴细胞对B细胞增殖的抑制作用，而胎儿Ig阴性淋巴细胞则无法发挥这种作用。将Ig阴性淋巴细胞分离成各种亚群表明，这种抑制作用是由T细胞发挥的。巨噬细胞和裸细胞在抑制中作用很小或没有作用。讨论了这种现象与传染性单核细胞增多症期间及之后EBV感染和从EBV感染中恢复的相关性。
