Bondarenko V M, Zhalko-Titarenko V P
Zh Mikrobiol Epidemiol Immunobiol. 1991 Aug(8):23-7.
The problem of the stability of the development of Shigella population in the intestine, depending on the dose of the infective agent, is analyzed. The agent is reproduced in the intestinal mucosa in short cycles, starting with adhesion and followed by penetration, intracellular multiplication and, finally, emission of free bacteria and hulled tops of villi with Shigella intracellular microcolonies. This form of emission maintains high concentration of bacteria and ensures, in case of the adhesion of hulled material, high local concentration provoking the repetition of the cycle. Depending on the dose, chains of cycles either progressively develop or maintain a constant level, or become extinct. Stable development of the chains of infectious cycles forms a focus of infection in the body (in the intestine). The growth of the populations of infective agents in live tissues, following the chain of cycles, produces a new type of microbial culture, differing from the types obtained by batch and flow cultivation. The aggregation and accumulation of infective agents in the hulled material is the particular case of the formation of infections, highly active particles and accumulations of infective agents, ensuring the development of infection with a relatively small number of organisms.
分析了志贺氏菌群体在肠道内的发育稳定性问题，该问题取决于感染因子的剂量。感染因子在肠黏膜中以短周期进行繁殖，起始于黏附，随后是穿透、细胞内增殖，最后是释放游离细菌以及带有志贺氏菌细胞内微菌落的绒毛脱壳顶端。这种释放形式维持了细菌的高浓度，并确保在脱壳物质黏附的情况下，引发循环重复的高局部浓度。根据剂量不同，循环链要么逐渐发展，要么维持恒定水平，要么灭绝。感染循环链的稳定发展在体内（肠道内）形成感染病灶。沿着循环链，感染因子群体在活组织中的生长产生了一种新型微生物培养物，不同于通过分批培养和连续培养获得的类型。感染因子在脱壳物质中的聚集和积累是感染形成的特殊情况，是高活性颗粒和感染因子聚集体，确保在相对少量生物体的情况下感染的发展。
